Study of Pulmonary Function Test Parameters in Patients of a Tertiary Care Hospital: An Observational, Prospective Study
Background: Pulmonary function test (PFT) is a valuable tool to evaluate respiratory system. It helps in assessing severity of airway obstruction and functional degradation through different patterns of abnormalities and helps to establish a diagnosis.
Methods: This was an observational, prospective study conducted for three months on thrice-weekly basis in the Department of Pharmacology using Spiro Excel software. FVC, FEV1, FEV1/ FVC%, PEFR and FEF 25-75 % were compared in context of gender and age with one-tail unpaired t-test. Interpretation of PFTs, i.e. Normal, Obstructive, Restrictive, and Mixed were compiled and categorized on basis of gender. Age group based smoking habit was analyzed. The parameters and interpretation of PFTs were compared between smokers and non-smokers.
Results: In this study 90 patients were enrolled; 71 were males and 19 were females. The majority of patients (40, 44.4%) were about 18-38 years. Mean and standard deviation of PFT parameters were significantly higher for males. The interpretation of PFT showed 41 normal and 49 abnormal results. On gender-based analysis, 41 (57.7%) males and 8 (42.1%) females showed abnormal PFT. On basis of smoking habit, maximum smokers (43.5%) were about 18-38 years of age. Mean values of PFT parameters were compared and were found to be significantly reduced in smokers.
Conclusions: This study showed that smoking has deleterious effect on pulmonary functions. Hence, cessation of smoking should be encouraged to prevent further decline. Spirometry can provide information on pulmonary function which may increase awareness among smokers, and can influence them to quit smoking.
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