Comparative Analysis of Indices of the Liver Function Tests in Patients with and without Non- Alcoholic Fatty Liver Disease at a Teaching Hospital in Hapur
Non-Alcoholic fatty liver disease (NAFLD) has become a worldwide health concern with increase in the global incidence of obesity and it is now considered the hepatic component of the metabolic syndrome.
Aims and Objective:
The study’s aim was to compare the indices of the Liver Function tests in compensated chronic liver disease patients with and without NAFLD.
Materials and Methods:
A total of 100 consecutive patients with compensated chronic liver disease were recruited into the study. A structured questionnaire was administered to obtain relevant socio-demographic data. NAFLD was diagnosed based on clinical, biochemical, ultrasonographic and in a few histological features. The Adult Treatment Panel III criteria were used to identify patients with the metabolic syndrome.
In our study, 100 participants were recruited into study. 40 out of 60 patients (67%) showed grade-1 fatty liver findings and 20 out of 60 patients (33%) showed grade-2 fatty liver. Approximately 19% had fatty liver finding. The mean (SD) age of persons with NAFLD was 45.12 (±8.07) years compared to 47.49(±11.79) years for persons without NAFLD. The difference was not statistically significant (p=0.2). Body mass index (BMI), central obesity (waist circumference), fasting blood sugar, blood pressure, total cholesterol and triglycerides were significantly higher in the NAFLD group (p= <0.05) respectively.
Indices of the deranged Liver functions were more prevalent in persons with NAFLD. It is recommended that patients with NAFLD be screened for metabolic syndrome and appropriate therapy instituted to decrease the risk of both hepatic and cardiovascular complications.
2. Reference: Wanless IR, Lentz JS. Fatty Liver Hepatitis (Steatohepatitis) and Obesity: An Autopsy Study with Analysis of Risk Factors. Hepatology 1990; 12:1106 -1110
3. Reference: Lazo M, Clark JM, The epidemiology of Non Alcoholic LFatty Liver Disease: A Global Pepspective, Semin. Liver Dis, 2008; 28:339 – 350
4. Refernce: Schwimmer JB, Mc Greal N, Deutsch R et al. Influence of gender, race and ethnicity on suspected fatty liver in obese adolescevts. Pediatrics 2005; 115:e561 – 565
5. Strauss RS, LBarlow SE, Dietz WH, Prevalence of Abnormal Serum Aminotranseerase Values In overweight and obese Adolescents. J. Pedtatr. 200; 136:727 – 733
6. Park HS, Han JH, Choi KM, KIN SM, Relation between Elevated Serum Alanine Aminotransferase and Metabolic Syndrome In Korean Adolescents. Am. J. Clin. Nutr. 2005; 82:104
7. a) J.G.Fan,steatohepatitis studies in china,shijie huaren xiaohuazazhi,9(2001); H.J.Zhang,H.Zhuang,X.E.Liu,advance in epidemiological study of fatty liver disease.zhonghua liu xing bing xue za zhi,25(2004)
7. b) Newton JL, Dig Dis, 2010; 28 (1); 214-9, E pub 2010 May 7. Biomedical Research Centre in Ageing Liver Theme, Newcastle university, UK Julia. Newton @ nuth.nhs.uk, pub Med, S. Karger AG, Basel, Switzerland.
8. Kagansky N, Levy S, Keter D, Rimon E, Taiba Z, Fridman Z, Berger D, Knobler H, Malnick S. (Dept. of Geniatric Medicine & Dept. of Gastroenterology, Kaplan Herzfeld Medical Center, Rehovol, Israel.
9. Kern WH, Heger AH, Payne JH, Dewind LT. Fatty metamorphosis of the liver in morbid obesity. Arch Pathol 1973;96:342–346.
10. Bacon BR, Farahvash MJ, Janey CG, Neurchwonder Tetai BA, Non-alcoholic Hepatitis, An expanded clinical entity. Gastroenterology 1994; 107: 1103-9.
11. Wanless IR, Lentz JS. Fatty liver hepatitis (steolohepatitis) and obesity. An autopsy study with analysis of risk factors. Hepatology 1990; 12 :1106-1110.
12. Powell EE, Cooksky WG, Hanson R, Searle J, Halliday JW, Powell LW. The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology. 1990;11:74-80.
13. Wanless IR, Lentz JS. Fatty liver hepatitis (steolohepatitis) and obesity. An autopsy study with analysis of risk factors. Hepatology 1990; 12 :1106-1110.
14. Wanless IR, Lentz JS. Fatty liver hepatitis (steolohepatitis) and obesity. An autopsy study with analysis of risk factors. Hepatology 1990; 12 :1106-1110.
15. Schult A, et al, SC and J Gastroenterol 2011 Jan; 46 (6); 738-44. E pub 2011 feb. 28. Dept. of Med, Sahlgrenska university Hospital ostra, Gothenburg Sweden andreas, schult @vgregion.se.
16. Adler M, Schaffner F, Fatty liver hepatitis and cirrhosis in obese patients. AM J Med 1979; 67: 811-816.
17. Ludwig J, Viggiano RT. Mc Gill DB,et al Non-alcoholic steatohepatitis. Mayo clinic experiences with a hitherto unnamed disease. Mayo clinic Proc 1980; 55: 342-348.
18. Baldridge AD, Perez- Atayde AR, Graeme-Cook, F Higgin L, Lavine JE, Idiopathic steatohepatitis in childhood: a multicentric retrospective study. J Pediatrics: 1995; 127: 700-4.
19. Diel AM. Goodman Z, Ishak KG. Alcohol- like liver disease in non-alcoholic. A clinical and histopathological comparison with alcohol- induced liver injury. Gastroenterology 1989; 95: 1056-1060.
20. Younossi ZM, Gramilich T, Mitteoni CaA et al. Nonalcoholic Fatty Liver Disease in Patients with type 2 Diabetes, Clin. Gastroenterol. Heptol. 2004; 2:262
21. Marchesini G, Brizi M, Morselli –– 265 Labate AM et al. Association of insulin resistance. AM J. Med. 1999; 107:450 455 nonalcoholic fatty liver Disease
22. Assy N, Kaita K, Mymin D et al. Fatty Infiltration of Liver in Hyperlipidemic patients, Dig, Dis. Sci. 2000; 45: 19291934
23. Amarpurkar D, Kamani P, patel N, Gupte p, Kumar P, Agal S, Baijal R, lala S, Choudhary D, Deshpande A. (Ann Hepatol 2007 July-September 6(3); 161-3.
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